Drug Metabolism and Pharmacokinetics (DMPK)

Discovery ADME Screening Strategy

A host of DMPK in vitro and in vivo assays are readily available to probe the Absorption, Distribution, Metabolism and Excretion (ADME) properties of new molecular entities. I work with you to design resource sparing strategies that allow you to rapidly identify the most promising leads.

Human PK and dose predictions

Understanding exposure - response relationships are critical to translating in vitro and preclinical in vivo models to human PK and dose. I leverage a tiered approach to generate predictions based on your in vitro and in vivo DMPK and pharmacology data.

Translational PK/PD

Connecting PK with pharmacodynamic (PD) response requires rigorous problem solving and models linking biomarkers, target engagement and direct PD endpoints with exposure. I work with you to design experiments and generate data that drives your decision making.

Assessment of Potential Drug-Drug Interactions

Integrating in vitro inhibition and induction data into prediction of potential DDI liabilities allows risk assessment and management of potential liabilities. I help you navigate the complexities of interpreting data for metabolizing enzymes and transporters to ensure your regulatory submission packages are robust and appropriate.

Document Preparation for Regulatory Submissions